![]() Concomitantly, the high degree of interindividual variation in the current population facilitates fine mapping efforts to pinpoint the aetiologic polymorphisms. Consequently, Sardinia is an especially attractive venue for case-control genome wide association scans in common multifactorial diseases. These results suggest a largely pre-Neolithic settlement of the island with little subsequent gene flow from outside populations. ![]() ![]() A Bayesian full likelihood analysis (BATWING) indicated that the time from the most recent common ancestor (TMRCA) of I-M26, was 21.0 (16.0-25.5) thousand years ago (KYA) and that the population began to expand 14.0 (7.8-22.0) KYA. One haplogroup, I-M26, is rare or absent outside Sardinia and is very common (0.37 frequency) throughout the island, consistent with a founder effect. We found a high degree of interindividual variation but a homogenous distribution of the detected variability in samples from three separate regions of the island. For an unbiased assessment of genetic structure, we studied a combination of neutral Y-chromosome variants, 21 biallelic and 8 short tandem repeats (STRs) in 930 Sardinian males. Ribbed crew neck Long batwing sleeves with ribbed cuffs Ribbed hem Regular fit. Previous work suggested that the Sardinians are a relatively homogenous population, but some reports were contradictory and data were largely based on variants subject to selection. Buy Long Batwing Sleeve Waffle Top at Kmart. The prior knowledge of the genetic structure of this population is fundamental to establish the optimal design for association studies in these diseases. ![]() The island of Sardinia shows a unique high incidence of several autoimmune diseases with multifactorial inheritance, particularly type 1 diabetes and multiple sclerosis. ![]()
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